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Updated: Feb 9, 2026

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
Published on: January 17, 2012
Elevated serum eosinophil cationic protein and transforming growth factor-α levels in a patient with pemphigus
K Matsuyama1, M Tokuzumi1, T Takahashi1
1Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
Abstract:
Pemphigus vegetans (PVeg) is a rare variant of pemphigus, characterized by vegetating lesions mainly with antidesmoglein 3 antibodies. However, the pathomechanisms for PVeg is still unknown. We present a patient with PVeg mainly associated with antidesmocollin (Dsc)3 antibodies, who originally developed pemphigus foliaceus. Serum levels of eosinophil cationic protein and transforming growth factor (TGF)-α increased at the onset of PVeg in this patient. Thus, TGF-α might be involved in the formation of vegetating lesions in PVeg.
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