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Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
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Psychedelics and Personality.

Marc Aixalà1, Rafael G Dos Santos1,2,3, Jaime E C Hallak2,3

  • 1ICEERS Foundation (International Center for Ethnobotanical Education, Research and Services) , 08015 Barcelona , Spain.

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PubMed
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Psychedelics show promise for treating mood and anxiety disorders by altering brain activity. Further research is needed to fully understand their therapeutic mechanisms and limitations.

Keywords:
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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Clinical trials increasingly investigate psychedelics like psilocybin for mental health.
  • Serotonergic hallucinogens show potential in treating mood, anxiety, and substance use disorders.

Purpose of the Study:

  • To provide a critical overview of current psychedelic research.
  • To highlight the potential benefits and limitations of psychedelic-assisted therapies.

Main Methods:

  • Review of existing clinical trial data.
  • Analysis of proposed neurobiological mechanisms.
  • Critical evaluation of study designs and outcomes.

Main Results:

  • Evidence suggests psychedelics may effectively treat mood, anxiety, and substance use disorders.
  • Mechanisms involve changes in brain dynamics, particularly in 5-HT2A receptor-rich areas.
  • Observed effects may also relate to personality changes.

Conclusions:

  • Psychedelics represent a promising area for novel psychiatric treatments.
  • Further research is essential to elucidate mechanisms and address study limitations.
  • Careful consideration of therapeutic potential alongside existing challenges is crucial.