Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.2K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.2K
Role of Amygdala in Memory01:16

Role of Amygdala in Memory

1.3K
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
1.3K
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

2.6K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
2.6K
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

1.6K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.6K
Chronopharmacokinetics: Time-Dependent Pharmacokinetics01:20

Chronopharmacokinetics: Time-Dependent Pharmacokinetics

418
Chronopharmacokinetics studies the temporal change in drug absorption and elimination. These changes can be cyclical or non-cyclical. Cyclical changes occur over a regular interval, while non-cyclical changes occur over a longer, irregular period.
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...
418
The Integrated Rate Law: The Dependence of Concentration on Time02:39

The Integrated Rate Law: The Dependence of Concentration on Time

43.1K
While the differential rate law relates the rate and concentrations of reactants, a second form of rate law called the integrated rate law relates concentrations of reactants and time. Integrated rate laws can be used to determine the amount of reactant or product present after a period of time or to estimate the time required for a reaction to proceed to a certain extent. For example, an integrated rate law helps determine the length of time a radioactive material must be stored for its...
43.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ventral hippocampus and the contextual control of Pavlovian and instrumental behaviors.

Neurobiology of learning and memory·2026
Same author

Renewal of conditioned fear in a third context after either extinction or counterconditioning: Testing the effects of sex and hormones.

Behavioral neuroscience·2025
Same author

Robust renewal after extinction of remotely acquired Pavlovian conditioning.

Learning & memory (Cold Spring Harbor, N.Y.)·2025
Same author

Influence of context on extinguished appetitive conditioning in male and female rats.

Behavioral neuroscience·2025
Same author

Editorial: Cortico-hippocampal interactions during learning and memory.

Frontiers in behavioral neuroscience·2024
Same author

Retrosplenial cortex and aversive conditioning.

Frontiers in behavioral neuroscience·2024

Related Experiment Video

Updated: Feb 9, 2026

Simultaneous Two-photon In Vivo Imaging of Synaptic Inputs and Postsynaptic Targets in the Mouse Retrosplenial Cortex
16:45

Simultaneous Two-photon In Vivo Imaging of Synaptic Inputs and Postsynaptic Targets in the Mouse Retrosplenial Cortex

Published on: March 13, 2016

12.0K

Retrosplenial cortex has a time-dependent role in memory for visual stimuli.

Matthew Y Jiang1, Nicole E DeAngeli1, David J Bucci1

  • 1Department of Psychological and Brain Sciences.

Behavioral Neuroscience
|June 5, 2018
PubMed
Summary

The retrosplenial cortex (RSC) is crucial for retrieving remote fear memories associated with visual cues, but not immediate ones. This suggests the RSC supports long-term memory recall across different sensory modalities.

More Related Videos

Using Looming Visual Stimuli to Evaluate Mouse Vision
05:07

Using Looming Visual Stimuli to Evaluate Mouse Vision

Published on: June 13, 2019

12.3K
A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice
05:49

A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice

Published on: July 21, 2018

10.2K

Related Experiment Videos

Last Updated: Feb 9, 2026

Simultaneous Two-photon In Vivo Imaging of Synaptic Inputs and Postsynaptic Targets in the Mouse Retrosplenial Cortex
16:45

Simultaneous Two-photon In Vivo Imaging of Synaptic Inputs and Postsynaptic Targets in the Mouse Retrosplenial Cortex

Published on: March 13, 2016

12.0K
Using Looming Visual Stimuli to Evaluate Mouse Vision
05:07

Using Looming Visual Stimuli to Evaluate Mouse Vision

Published on: June 13, 2019

12.3K
A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice
05:49

A Behavioral Assay for Investigating the Role of Spatial Memory During Instinctive Defense in Mice

Published on: July 21, 2018

10.2K

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Background:

  • The retrosplenial cortex (RSC) plays a key role in spatial learning and memory.
  • Its involvement in discrete cue learning and memory is more selective and time-dependent.
  • Previous studies show RSC damage impairs long-term, but not short-term, fear memory retrieval for auditory cues.

Purpose of the Study:

  • To investigate if the RSC's time-dependent role in fear memory retrieval extends to visual cues.
  • To determine if the RSC is necessary for recalling remote cued fear memories across different sensory modalities.

Main Methods:

  • Rats underwent fear conditioning using a visual stimulus.
  • Lesions of the retrosplenial cortex (RSC) were induced either 1 day or 28 days post-conditioning.
  • Fear expression was measured to assess memory retrieval.

Main Results:

  • RSC lesions impaired fear expression when performed 28 days after visual cue conditioning.
  • RSC lesions did not affect fear expression when performed 1 day after conditioning.
  • These findings align with previous research on auditory cues.

Conclusions:

  • The retrosplenial cortex (RSC) is essential for the retrieval of remotely acquired cued fear memories.
  • This time-dependent role of the RSC in memory retrieval appears to be modality-independent.
  • The RSC is critical for accessing long-term associative memories across different sensory types.