Hand grip strength and cognitive function among elderly cancer survivors
Lin Yang1, Ai Koyanagi2,3, Lee Smith4
1Department of Epidemiology, Center for Public Health, Medical University of Vienna, Vienna, Austria.
Plos One
|June 5, 2018
Summary
Handgrip strength is linked to cognitive function in older cancer survivors. Increased strength correlated with better verbal fluency and processing speed in women, while men showed optimal cognitive function at moderate strength levels.
Area of Science:
- Gerontology
- Oncology
- Neuroscience
Background:
- Cancer survivors aged 60+ represent a growing population with potential long-term health challenges.
- Cognitive decline is a common concern among older adults, including cancer survivors.
- Handgrip strength is an indicator of overall physical health and muscle mass.
Purpose of the Study:
- To investigate the association between handgrip strength and cognitive function in cancer survivors aged 60 years and older.
- To explore potential differences in this association between genders.
Main Methods:
- Utilized data from two waves (2011-2014) of the National Health and Nutrition Examination Survey (NHANES).
- Assessed handgrip strength (kg) and cognitive function using the Animal Fluency Test (AFT) and Digital Symbol Substitution Test (DSST).
- Employed multiple linear regression models, accounting for complex survey designs and adjusting for relevant confounders.
Main Results:
- Among 383 cancer survivors, higher handgrip strength in women was associated with improved scores on AFT (verbal fluency) and DSST (processing speed).
- Men exhibited an inverted U-shaped association, with peak cognitive function observed at handgrip strength levels of 40-42 kg.
- Prevalent cancers included breast, prostate, colon, and cervix.
Conclusions:
- Handgrip strength, a modifiable factor, shows a significant association with cognitive functions in older cancer survivors.
- Further prospective studies are recommended to establish a causal relationship between handgrip strength and cognitive function in this population.
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