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Updated: Feb 9, 2026

Expression, Purification, and Antimicrobial Activity of S100A12
Published on: May 13, 2017
Synthesis of tritium-labeled cyadox, a promising antimicrobial growth-promoting agent with high specific activity
Sechenchogt Harnud1, Aiqun Zhang2, Zonghui Yuan3
1MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, Hubei 430070, P.R. China; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, Hubei 430070, P.R. China; Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Huazhong Agricultural University, Wuhan, Hubei 430070, P.R. China; Hubei Engineering Technology Center for Utilization of Botanical Functional Ingredients, Xiaogan 432000, P.R. China; College of Life Science and Technology,Hubei Engineering University, Xiaogan 432000, P.R. China.
Abstract:
Cyadox is a new antimicrobial growth-promoting agent for food-producing animals. Studies on radiolabeled compounds enable the use of sensitive radiometric analytical methods and help in the elucidation of metabolic and elimination pathways. In the present study, 6-[3H]-cyadox with a high specific activity of 2.08 Ci/mmol was prepared by the catalytic bromine-tritium exchange of 4-bromo-2-nitroaniline followed by a three-step microscale synthesis, giving a high yield between 36.16% and 94.75%.
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