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MiR-876-5p suppresses cell proliferation by targeting Angiopoietin-1 in the psoriasis

Rongna A1, Pei Yu2, Siyu Hao2

  • 1Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, China; Department of Dermatology, Heilongjiang Provincial Hospital, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|June 6, 2018
PubMed

Insights

MicroRNA-876-5p is downregulated in psoriasis, inhibiting keratinocyte proliferation and invasion by targeting Angiopoietin-1. This suggests miR-876-5p as a potential therapeutic target for psoriasis treatment.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Immunology

Background:

  • Psoriasis is an autoimmune disease involving abnormal keratinocyte proliferation.
  • MicroRNAs (miRNAs) are implicated in psoriasis pathogenesis.
  • The specific role of miR-876-5p in psoriasis requires further investigation.

Purpose of the Study:

  • To investigate the role of miRNA-876-5p in psoriasis.
  • To determine the molecular mechanisms underlying miR-876-5p's function in psoriasis.

Main Methods:

  • Analysis of miR-876-5p expression in patient tissues and blood.
  • Luciferase assay to confirm miR-876-5p targeting of Angiopoietin-1 (Ang-1).
  • Cell proliferation, cell cycle, invasion, and adhesion assays in response to miR-876-5p modulation.

Main Results:

  • miR-876-5p expression was significantly downregulated in psoriasis.
  • miR-876-5p directly targets the 3'UTR of Ang-1.
  • Overexpression of miR-876-5p inhibited keratinocyte proliferation, arrested cells in G0/G1 phase, and suppressed invasion and adhesion.
  • miR-876-5p suppressed Ang-1 expression, impacting PI3K/AKT/mTOR and ERK signaling pathways.

Conclusions:

  • miR-876-5p plays a suppressive role in psoriasis development.
  • miR-876-5p acts by inhibiting Ang-1 expression and downstream signaling pathways.
  • miR-876-5p represents a potential biomarker and therapeutic target for psoriasis.
Keywords:
Ang-1MigrationProliferationPsoriasismiR-876-5p

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