Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Frequency-dependent Selection01:21

Frequency-dependent Selection

24.2K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
24.2K
Leveling Effect01:29

Leveling Effect

1.4K
In acid-base chemistry, the leveling effect refers to the limitation imposed by the solvent on the strength of acids and bases in solution. When a base stronger than the solvent's conjugate base is used, it deprotonates the solvent until the base is entirely consumed, making it ineffective against weaker acids. Conversely, an acid stronger than the solvent's conjugate acid protonates the solvent until the acid is depleted, rendering it ineffective against weaker bases. Essentially, the...
1.4K
Arteries of Lower Limbs01:20

Arteries of Lower Limbs

4.8K
The external iliac artery transitions out of the body cavity, entering the femoral region of the lower leg, and is renamed the femoral artery at the point where it traverses the body wall. This artery is responsible for the distribution of blood to the thigh's deep muscles and the skin's ventral and lateral regions, achieved through several minor branches and the lateral deep femoral artery, which also spawns a lateral circumflex artery. The knee area receives blood from the genicular...
4.8K
Veins of Lower Limbs01:15

Veins of Lower Limbs

2.6K
The human body consists of an intricate network of veins responsible for the crucial task of blood drainage from the lower limbs. These veins can be categorized into two main types: deep veins and superficial veins.
Formed by the union of the medial and lateral plantar veins, the posterior tibial vein, rising through the calf muscle, assimilates the fibular vein. The anterior tibial vein, a superior extension of the foot's dorsalis pedis vein, merges with the posterior tibial vein at the...
2.6K
Fixed Action Patterns01:06

Fixed Action Patterns

17.7K
A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
17.7K
High-Level and Low-Level Awareness01:19

High-Level and Low-Level Awareness

785
Controlled processes in human consciousness represent high-alert mental states where individuals deliberately focus their attention on achieving specific goals. Controlled processes can be seen in situations like mastering new technology, where a person might become so absorbed that they ignore surrounding distractions. Such processes involve selective attention, requiring one to concentrate on particular elements of experience while disregarding others. These are governed by executive...
785

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Abundance in secret: a review of the genus <i>Leptobrachium</i> (Anura, Megophryidae) in India, with descriptions of two new species.

PeerJ·2026
Same author

The metamorphic transition of the frog mouth: from tadpole keratinized mouthparts to adult teeth.

Royal Society open science·2025
Same author

Subterranean salamanders lean into mechanical sense following vision loss.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Increasing the impact of vertebrate scientific collections through 3D imaging: The openVertebrate (oVert) Thematic Collections Network.

Bioscience·2024
Same author

A new snouted treefrog (Anura, Hylidae, Scinax) from fluvial islands of the Juruena River, southern Brazilian Amazonia.

PloS one·2024
Same author

Conserved chromatin and repetitive patterns reveal slow genome evolution in frogs.

Nature communications·2024

Related Experiment Video

Updated: Feb 9, 2026

Chemical Amputation and Regeneration of the Pharynx in the Planarian Schmidtea mediterranea
06:14

Chemical Amputation and Regeneration of the Pharynx in the Planarian Schmidtea mediterranea

Published on: March 26, 2018

11.5K

Amputation level-dependent patterning in urodele limb regeneration.

Charles E Dinsmore1, James Hanken2

  • 1Department of Anatomy, Rush Medical College, Chicago, Illinois 60612.

Journal of Morphology
|June 6, 2018
PubMed
Summary
This summary is machine-generated.

Salamander limb regeneration shows unique skeletal patterns. Amputation level influences fusion patterns in regenerated mesopodia, affecting limb development.

More Related Videos

Inhibition of Wound Epidermis Formation via Full Skin Flap Surgery During Axolotl Limb Regeneration
04:24

Inhibition of Wound Epidermis Formation via Full Skin Flap Surgery During Axolotl Limb Regeneration

Published on: June 24, 2020

3.6K
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.8K

Related Experiment Videos

Last Updated: Feb 9, 2026

Chemical Amputation and Regeneration of the Pharynx in the Planarian Schmidtea mediterranea
06:14

Chemical Amputation and Regeneration of the Pharynx in the Planarian Schmidtea mediterranea

Published on: March 26, 2018

11.5K
Inhibition of Wound Epidermis Formation via Full Skin Flap Surgery During Axolotl Limb Regeneration
04:24

Inhibition of Wound Epidermis Formation via Full Skin Flap Surgery During Axolotl Limb Regeneration

Published on: June 24, 2020

3.6K
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.8K

Area of Science:

  • Developmental Biology
  • Regenerative Medicine
  • Comparative Anatomy

Background:

  • Salamander limb regeneration is a key model for studying developmental processes.
  • Native and regenerated limbs exhibit distinct skeletal patterning, particularly in the mesopodium.
  • Understanding these differences is crucial for advancing regenerative biology.

Purpose of the Study:

  • To compare mesopodial skeletal patterns in native and regenerated limbs of the salamander *Plethodon cinereus*.
  • To investigate the influence of amputation level on fusion patterns in regenerated mesopodia.
  • To elucidate the relationship between amputation site and specific fusion combinations in limb regeneration.

Main Methods:

  • Comparative analysis of mesopodial skeletal morphology in native and regenerated limbs.
  • Limb regeneration experiments involving amputation at different levels (proximal and distal).
  • Detailed examination of skeletal element fusions in the mesopodia of regenerates.

Main Results:

  • Native limbs display anteroposterior axis fusions; regenerated limbs show proximodistal axis fusions.
  • The proximodistal fusion axis in regenerates is consistent regardless of amputation level.
  • Fusion combination frequencies are sensitive to amputation level, with proximal amputation favoring preaxial fusions and distal amputation favoring postaxial fusions.

Conclusions:

  • Limb regeneration in *Plethodon cinereus* involves distinct skeletal patterning mechanisms compared to native limb development.
  • Amputation level is a critical factor modulating the specific skeletal outcomes of limb regeneration.
  • These findings contribute to the understanding of pattern formation during vertebrate limb regeneration.