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Formation of Complex Ions03:45

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A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
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Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
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Small-Molecule Lanthanide Complexes Probe for Second Near-Infrared Window Bioimaging.

Yanling Yang1, Peiyuan Wang1, Lingfei Lu1

  • 1Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Chemistry for Energy Materials , Fudan University , Shanghai 200433 , P. R. China.

Analytical Chemistry
|June 6, 2018
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Summary

A new near-infrared II (NIR-II) lanthanide complex, Nd-DOTA, offers rapid excretion and superior imaging for detecting small tumors. This probe enhances surgical precision, potentially accelerating clinical translation for advanced bioimaging.

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Area of Science:

  • Biomedical Imaging
  • Nanotechnology
  • Medical Diagnostics

Background:

  • Developing novel fluorescent probes for the second near-infrared (NIR-II) window (1000-1700 nm) is crucial for deep tissue penetration.
  • Existing NIR-II fluorophores often suffer from slow excretion and reticuloendothelial system retention.
  • The limitations of current probes hinder their clinical application despite the advantages of NIR-II imaging.

Purpose of the Study:

  • To develop a novel, rapidly excreted NIR-II lanthanide complex for enhanced bioimaging.
  • To evaluate the imaging performance, tissue penetration, and tumor-to-normal tissue ratio of the new probe.
  • To assess the potential for clinical translation of this new class of NIR-II probes.

Main Methods:

  • Synthesis and characterization of a novel lanthanide complex, Nd-DOTA.
  • In vivo evaluation of Nd-DOTA's pharmacokinetic profile, focusing on renal excretion.
  • Comparison of Nd-DOTA's NIR-II imaging performance against clinically approved indocyanine green (ICG).
  • Assessment of Nd-DOTA's efficacy in delineating small ovarian metastases in vivo.

Main Results:

  • Nd-DOTA demonstrated rapid renal excretion (over 50% within 3 hours) with a low molecular mass (0.54 kDa).
  • Nd-DOTA exhibited superior NIR-II imaging quality, photostability, and deep tissue penetration (7 mm) compared to ICG.
  • High tumor-to-normal tissue ratios were achieved, enabling precise surgical delineation of small metastases (≤1 mm).

Conclusions:

  • Nd-DOTA represents a promising, rapidly cleared NIR-II probe with excellent imaging capabilities for surgical guidance.
  • Its structural similarity to the MRI contrast agent Gd-DOTA facilitates future clinical translation.
  • This work advances the development of effective NIR-II probes for sensitive and precise medical diagnostics.