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Updated: Feb 9, 2026

Inducible and Reversible Dominant-negative DN Protein Inhibition
Published on: January 7, 2019
Decrease in Serum Amyloid a Protein Levels Following Three-month Stays in Negatively Charged Particle-dominant Indoor
Suni Lee1, Shoko Yamamoto1, Yasumitsu Nishimura1
1Department of Hygiene, Kawasaki Medical School, 577 Mastushima, Kurashiki 701-0192, Japan.
Exposure to negatively charged particle-dominant indoor air conditions (NCPDIAC) significantly decreased serum amyloid A (SAA) levels in volunteers. This reduction may help prevent cardiovascular and atherosclerotic changes.
Area of Science:
- Environmental Health
- Biochemistry
- Cardiovascular Research
Background:
- Oxidative stress is linked to cardiovascular and atherosclerotic diseases.
- Serum adipokines and cytokines are biomarkers of oxidative stress.
- Indoor air quality can influence physiological responses.
Purpose of the Study:
- To investigate the impact of negatively charged particle-dominant indoor air conditions (NCPDIAC) on serum adipokines and cytokines.
- To examine changes during 'Off to On' and 'On to Off' exposure periods.
Main Methods:
- Seven volunteers participated in repeated 'Off to 3 months On' (ON trials) and 'On to 3 months Off' (OFF trials) periods.
- Serum samples were analyzed for changes in specific biomarkers.
Main Results:
- Serum amyloid A (SAA) levels showed a significant decrease in most participants during the ON trials.
- No significant changes were noted in other measured adipokines or cytokines.
Conclusions:
- The observed decrease in SAA, an acute phase protein, suggests potential protective effects against cardiovascular and atherosclerotic changes.
- NCPDIAC may play a role in mitigating inflammation associated with these conditions.
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