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Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
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Cytomegalovirus: Shape-Shifting the Immune System.
Gaëlle Picarda1, Chris A Benedict2,3
1Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; and.
Journal of Immunology (Baltimore, Md. : 1950)
|June 6, 2018
Summary
Cytomegalovirus (CMV), a common herpesvirus, significantly impacts immune system variation. This review details how CMV infection shapes host immunity and influences overall health.
Area of Science:
- Immunology
- Virology
- Human Health
Background:
- Immune system variation is influenced by extrinsic factors.
- Cytomegalovirus (CMV), a beta-herpesvirus (HHV-5), profoundly impacts immune responses.
- The majority of the global population is CMV-positive, experiencing lifelong infection.
Purpose of the Study:
- To review how Cytomegalovirus (CMV) shapes host immunity.
- To discuss the impact of CMV infection on overall health.
- To elucidate the distinct infection phases and immune control mechanisms of CMV.
Main Methods:
- Literature review of systems-based approaches.
- Analysis of immune modulatory strategies employed by CMV.
- Examination of host defense mechanisms against CMV across infection phases.
Main Results:
- CMV establishes lifelong persistence through distinct infection phases.
- Each phase of CMV infection requires unique host immune responses.
- CMV utilizes multiple immune-modulatory strategies for persistence.
Conclusions:
- CMV significantly shapes the human immune system.
- Understanding CMV's impact on immunity is crucial for assessing overall health.
- CMV infection presents a complex interplay between virus and host immune system.
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