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Related Experiment Video

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Simple and Robust in vivo and in vitro Approach for Studying Virus Assembly
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Robust nonequilibrium pathways to microcompartment assembly.

Grant M Rotskoff1,2, Phillip L Geissler3

  • 1Courant Institute of Mathematical Sciences, New York University, New York, NY 10002.

Proceedings of the National Academy of Sciences of the United States of America
|June 6, 2018
PubMed
Summary
This summary is machine-generated.

Cyanobacteria use nonequilibrium processes to reliably assemble protein microcompartments, similar to carboxysomes, for efficient carbon fixation. This discovery offers insights into nanoscale encapsulation and carboxysome engineering.

Keywords:
carboxysomenonequilibrium dynamicsself-assembly

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Area of Science:

  • Biochemistry
  • Biophysics
  • Systems Biology

Background:

  • Cyanobacteria utilize protein-based microcompartments, such as carboxysomes, to concentrate enzymes for carbon dioxide fixation.
  • Previous models suggested these microcompartments form through stable, equilibrium self-assembly, akin to viral capsids.

Purpose of the Study:

  • To investigate an alternative, nonequilibrium mechanism for microcompartment assembly in cyanobacteria.
  • To model the dynamics of microcompartment formation, focusing on size, shape, and shell properties.

Main Methods:

  • Developed and simulated a molecular model to resolve microcompartment structure and assembly.
  • Created a simplified mathematical model integrating nucleation theory and continuum elasticity.

Main Results:

  • Simulations revealed a metastable assembly pathway, producing structures resembling carboxysomes with defined size and faceted shells.
  • The simplified model successfully captured the essential dynamics of microcompartment assembly.

Conclusions:

  • Microcompartment assembly in cyanobacteria is driven by a reliable, nonequilibrium process, not just equilibrium self-assembly.
  • Understanding these dynamics provides control over nanoscale encapsulation and potential for carboxysome engineering.