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The Glucose-Regulated MiR-483-3p Influences Key Signaling Pathways in Cancer

Felice Pepe1, Rosa Visone2,3, Angelo Veronese4,5

  • 1Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA. Felice.Pepe@osumc.edu.

Cancers
|June 6, 2018
PubMed

Insights

MicroRNA-483-3p, originating from the hsa-mir-483 gene, influences key cancer pathways like TP53 and Wnt/β-catenin. Its dysregulation is linked to cancer development and aberrant glucose metabolism.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • The hsa-mir-483 gene, located within the IGF2 locus, produces miR-483-5p and miR-483-3p.
  • miR-483-3p expression is regulated by the CTNNB1/USF1 complex and is independent of its host gene, IGF2.

Purpose of the Study:

  • To review recent findings on miR-483-3p.
  • To elucidate its role in physiological and pathological conditions, particularly in cancer and the TP53 pathway.

Main Methods:

  • Literature review of studies on miR-483-3p.
  • Analysis of miR-483-3p's targets and associated signaling pathways.

Main Results:

  • miR-483-3p targets genes in Wnt/β-catenin, TGF-β, and TP53 pathways (e.g., CTNNB1, SMAD4, IGF1, BBC3).
  • It influences tissue-specific functions like insulin and melanin production, and cellular processes including proliferation and survival.
  • Overexpression of miR-483-3p is linked to cancer, potentially inhibiting TP53-induced apoptosis and contributing to aberrant glucose metabolism.

Conclusions:

  • miR-483-3p plays a significant role in both normal physiology and disease.
  • Its oncogenic potential is associated with key cancer genes (TP53, CTNNB1) and cancer hallmarks like altered metabolism.
  • Further research into miR-483-3p is crucial for understanding cancer biology and developing therapeutic strategies.
Keywords:
CTNNB1TP53cancerchemoresistancemetabolismmiR-145-5pmiR-483-3p

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