Effects of Multi-Session Repetitive Transcranial Magnetic Stimulation on Motor Control and Spontaneous Brain Activity
Zhu Liu1, Huizi Ma1, Victoria Poole2
1Department of Neurodegenerative Disease, Centre of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Frontiers in Behavioral Neuroscience
|June 6, 2018
Summary
Repetitive transcranial magnetic stimulation (rTMS) improved motor control in multiple system atrophy (MSA) patients by enhancing brain network complexity. This non-invasive treatment showed promise for alleviating motor dysfunction in MSA.
Area of Science:
- Neuroscience
- Neurology
- Biomedical Engineering
Background:
- Multiple system atrophy (MSA) is characterized by impaired motor control due to cerebellar and neural network dysfunction.
- Resting-state brain activity is altered in MSA, impacting motor control.
- Repetitive transcranial magnetic stimulation (rTMS) can modulate brain network activity and improve behavior in neurodegenerative diseases.
Purpose of the Study:
- To investigate the effect of a multi-session rTMS intervention on motor control in MSA patients.
- To determine if rTMS-induced improvements in motor control correlate with changes in resting-state brain activity.
- To assess the feasibility and safety of rTMS for MSA.
Main Methods:
- Nine participants with MSA received daily 5 Hz rTMS sessions for five days, targeting the cerebellum and bilateral primary motor cortex (M1).
- Motor control was assessed using the Unified Multiple System Atrophy Rating Scale (UMSARS) before and after the intervention.
- Resting-state functional magnetic resonance imaging (fMRI) and multiscale entropy analysis quantified brain activity complexity within functional cortical networks.
Main Results:
- The rTMS intervention was safe, well-tolerated, and led to significant improvements in motor control scores.
- Seven out of nine participants showed enhanced motor function post-intervention.
- Increased resting-state complexity in the motor network correlated significantly with improved motor control.
Conclusions:
- A five-session rTMS intervention targeting the cerebellum and M1 is feasible and safe for MSA patients.
- Preliminary findings suggest rTMS may alleviate motor dysfunction in MSA.
- Further controlled trials are needed to confirm rTMS's therapeutic potential and its effects on brain activity dynamics.
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