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Age-Related Decrease in Stress Responsiveness and Proactive Coping in Male Mice.

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As mice age, proactive coping and stress response decrease. Fear memory consolidation is linked to stress and coping, while memory maintenance is mainly influenced by stress responsiveness and hippocampal glucocorticoid receptor expression.

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Area of Science:

  • Neuroscience
  • Behavioral Biology
  • Aging Research

Background:

  • Coping strategies are crucial for managing stress.
  • Proactive coping involves anticipating and acting on changes, while reactive coping responds to events.
  • Age-related changes in coping and stress processing are not well understood.

Purpose of the Study:

  • To investigate age-related changes in coping strategies and stress responsiveness in mice.
  • To examine how age influences the processing of conditioned fear memory.
  • To explore the relationship between coping style, stress, and fear memory across the lifespan.

Main Methods:

  • Assessed coping strategies using active avoidance tests and shock prod responses in 2-, 12-, and 23-month-old mice.
  • Measured stress responsiveness via corticosterone levels.
  • Evaluated fear memory consolidation and extinction, and the maintenance of extinct fear memory.
  • Analyzed the expression of hippocampal glucocorticoid receptor (GR) and co-chaperones.

Main Results:

  • Proactivity in coping and stress responsiveness decreased with age.
  • Fear memory consolidation was negatively correlated with stress responsiveness and proactivity.
  • Maintenance of extinct fear memory was negatively correlated with stress responsiveness but not coping style.
  • Hippocampal GR expression increased with age, particularly at 12 months.

Conclusions:

  • Stress responsiveness and proactive coping decline with aging in mice.
  • Fear memory consolidation is influenced by stress and coping, while memory maintenance is primarily linked to stress responsiveness.
  • Hippocampal glucocorticoid receptor expression may play a significant role in age-dependent fear memory processing, independent of coping style.