Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

4.5K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
4.5K
Microbial Morphologies01:29

Microbial Morphologies

3.8K
Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...
3.8K
Microbial Fermentation01:23

Microbial Fermentation

1.6K
Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...
1.6K
Microbial Classification System01:24

Microbial Classification System

1.2K
Classification is the process of organizing organisms into hierarchically inclusive groups based on their phenotypic similarities or evolutionary relationships. A species comprises one or more strains, and closely related species are grouped into genera. Genera are further classified into families, families into orders, orders into classes, and so forth, up to the domain level, which is the broadest taxonomic rank derived from a combination of phenotypic and genotypic data.The nomenclature of...
1.2K
Microbial Nutrition01:28

Microbial Nutrition

1.4K
Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...
1.4K
Microbial Growth Media01:27

Microbial Growth Media

2.2K
Microbial growth media are essential tools in microbiology, providing the nutrients and conditions necessary to cultivate and study microorganisms. These media are categorized by their composition, consistency, and functional roles, enabling researchers to investigate microbial physiology, behavior, and interactions.Types and Consistencies of Growth MediaGrowth media can be solid, liquid, or semisolid. Solid media, often agar-based, allow visible colony growth for isolation and enumeration.
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of patient-reported taxane-induced peripheral neuropathy on dose reductions or worsening quality of life in Black women with breast cancer: Analysis from ECOG-ACRIN EAZ171.

Cancer·2026
Same author

Impact of Race, Socioeconomic Status, and Clinicopathologic Features on Clinical Outcomes in Triple-Negative Breast Cancer in the ECOG-ACRIN EA1131 Trial.

JCO oncology advances·2026
Same author

Human oncogenic herpesvirus latency proteins activate NEK2 to promote chromosomal instability and tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Protocol to investigate replication kinetics of Kaposi's sarcoma-associated herpesvirus using single-molecule analysis of replicated DNA.

STAR protocols·2025
Same author

Sinonasal Inverted Papilloma and Clinical Significance of Dysplasia: A Multi-Institutional Study.

The Laryngoscope·2025
Same author

Cervical and Tumor-Associated Microbiomes in Botswana Women With and Without HIV With Carcinoma of the Cervix Before and After Definitive Chemoradiation.

JCO global oncology·2025
Same journal

Mapping the multigenomic human system: structural asymmetry and interface gaps in host-exogenous biological interactions.

Frontiers in microbiology·2026
Same journal

Bacterial resistance across habitats: from German schools to the International Space Station.

Frontiers in microbiology·2026
Same journal

Correction: Unlocking plant growth-promoting traits of endophytic actinobacteria isolated from <i>Anacyclus pyrethrum</i>, an endemic medicinal plant of the Aguelmam azegza region, Morocco.

Frontiers in microbiology·2026
Same journal

Research progress on <i>Avibacterium paragallinarum</i> and related bacterial and viral diseases in poultry and their mixed infections.

Frontiers in microbiology·2026
Same journal

Development and validation of a quantitative method for the enumeration of <i>Salmonella enterica</i> serovar Infantis from environmental poultry feces based on most probable number approach followed by confirmatory qPCR.

Frontiers in microbiology·2026
Same journal

Multi-omics insights into the microbial and metabolic drivers of regional flavor diversity in Guizhou traditional fermented fish.

Frontiers in microbiology·2026
See all related articles

Related Experiment Video

Updated: Feb 9, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

18.9K

Distinct Microbial Signatures Associated With Different Breast Cancer Types.

Sagarika Banerjee1, Tian Tian2, Zhi Wei2

  • 1Tumor Virology Program, Department of Otorhinolaryngology-Head and Neck Surgery and Microbiology, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Frontiers in Microbiology
|June 6, 2018
PubMed
Summary
This summary is machine-generated.

The microbiome differs across breast cancer types. Researchers identified unique microbial signatures in triple-negative and triple-positive breast cancers, offering new insights into cancer development and treatment.

Keywords:
HER2 positive breast cancerendocrine receptor positive breast cancermicrobiometriple negative breast cancertriple positive breast cancer

More Related Videos

Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography
10:10

Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography

Published on: July 29, 2011

15.7K
Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

7.1K

Related Experiment Videos

Last Updated: Feb 9, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

18.9K
Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography
10:10

Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography

Published on: July 29, 2011

15.7K
Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

7.1K

Area of Science:

  • Microbiology
  • Oncology
  • Genomics

Background:

  • Dysbiosis, an imbalance in the gut microbiome, is linked to various diseases, including cancer.
  • Breast cancer remains a significant cause of cancer-related mortality in women worldwide.

Purpose of the Study:

  • To investigate and compare the microbiome diversity across four major breast cancer subtypes: ER-positive, triple-positive, Her2-positive, and triple-negative.
  • To identify unique and common microbial signatures associated with each breast cancer type.

Main Methods:

  • Utilized whole genome and transcriptome amplification.
  • Employed a pan-pathogen microarray (PathoChip) to detect viral, bacterial, fungal, and parasitic signatures.
  • Validated findings using PCR and Sanger sequencing.
  • Performed hierarchical cluster analysis on microbial signatures to identify patterns.

Main Results:

  • Identified distinct microbial signatures specific to triple-negative and triple-positive breast cancers.
  • Observed shared microbial signatures between ER-positive and Her2-positive breast cancer subtypes.
  • Detected unique and common microbial signatures across the investigated breast cancer types.

Conclusions:

  • Microbial signatures vary significantly among different breast cancer subtypes.
  • These distinct microbial profiles offer novel avenues for understanding breast cancer prognosis, treatment strategies, and clinical outcomes.
  • Further research into the role of microorganisms in breast cancer development and progression is warranted.