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Sonosensitive MRI Nanosystems as Cancer Theranostics: A Recent Update
Francesca Garello1, Enzo Terreno1
1Molecular and Preclinical Imaging Centers, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Frontiers in Chemistry
|June 6, 2018
Summary
Sonosensitive Magnetic Resonance Imaging (MRI) agents offer targeted cancer therapy by using ultrasound to trigger drug release. These agents show improved therapeutic outcomes compared to traditional methods, suggesting clinical potential.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Sonosensitive Magnetic Resonance Imaging (MRI) agents are crucial for developing advanced cancer therapies.
- These agents utilize nano/microvesicles with biocompatible membranes, responsive to ultrasound, and an aqueous core containing MRI probes and therapeutic agents.
Purpose of the Study:
- To review key design principles for sonosensitive MRI agents.
- To provide an overview of current approaches in sonosensitive MRI agent development.
Main Methods:
- Examination of design considerations for sonosensitive MRI agents.
- Overview of various formulation and ultrasound triggering strategies.
Main Results:
- Ultrasound-triggered drug release generally leads to significantly better therapeutic outcomes than traditional cancer therapies.
- Preclinical studies, despite varied settings, indicate promising results for these advanced agents.
Conclusions:
- Sonosensitive MRI agents represent a promising strategy for targeted cancer treatment.
- Optimized sonosensitive MRI agents show potential for clinical translation due to improved therapeutic efficacy.
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