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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

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Hemodynamic impact of percutaneous left atrial appendage closure in patients with paroxysmal atrial fibrillation

Lluis Asmarats1, Mathieu Bernier1, Gilles O'Hara1

  • 1Quebec Heart & Lung Institute, Laval University, 2725 chemin Ste-Foy, Quebec City, Quebec, G1V 4G5, Canada.

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
|June 6, 2018
PubMed

Insights

Percutaneous left atrial appendage (LAA) closure effectively prevents thromboembolic events in atrial fibrillation (AF) patients. This study found that LAA closure does not significantly alter left atrial or ventricular function, offering a safe alternative to anticoagulation.

Area of Science:

  • Cardiology
  • Medical Devices
  • Cardiac Electrophysiology

Background:

  • Percutaneous left atrial appendage (LAA) closure is an established alternative to anticoagulation for preventing thromboembolic events in atrial fibrillation (AF) patients.
  • Limited data exist regarding the impact of LAA closure on cardiac function.

Purpose of the Study:

  • To evaluate the acute hemodynamic effects of percutaneous LAA closure on left atrial and ventricular function in patients with paroxysmal AF.

Main Methods:

  • The study included 31 patients with paroxysmal AF undergoing successful percutaneous LAA closure.
  • Transthoracic echocardiography was performed at baseline and post-procedure.
  • Cardiac computed tomography (CT) with 3D reconstruction was used in a subset of patients to assess LAA volume.

Main Results:

  • Left ventricular systolic function and left atrial volumetric indexes remained unchanged post-LAA closure.
  • No significant alterations in left ventricular or left atrial stroke volume were observed.
  • The LAA constituted approximately 10% of the total left atrial volume, with no correlation found between LAA/LA ratio and changes in stroke volume.

Conclusions:

  • Percutaneous LAA closure does not induce significant acute changes in left atrial or left ventricular function.
  • The procedure is hemodynamically neutral concerning cardiac function in patients with paroxysmal AF.
Abstract

Keywords:
Atrial fibrillationEchocardiographyPercutaneous left atrial appendage closureStroke volume

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