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HLA genetics in bipolar disorder.

R Tamouza1,2,3, J Oliveira1,2, B Etain2,4

  • 1INSERM, U955, Translational Psychiatry, Paris-East University, School of Medicine, AP-HP, DHU PePSY, Pole of Psychiatry, Henri Mondor University Hospital, Créteil, France.

Acta Psychiatrica Scandinavica
|June 6, 2018
PubMed
Summary
This summary is machine-generated.

Human leukocyte antigen (HLA) variations are linked to Bipolar Disorder (BD) risk and clinical features. Specific HLA sub-haplotypes are associated with rapid cycling, suicidal behaviors, and disease onset in BD patients, suggesting HLA-mediated inflammatory processes.

Keywords:
HLA haplotypesbipolar disorderinflammationpolarity at onsetrapid cyclingsuicidal behavior

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Area of Science:

  • Immunogenetics
  • Psychiatric Genetics
  • Human Leukocyte Antigen (HLA) System

Background:

  • Bipolar Disorder (BD) is associated with dysregulated adaptive immune processes.
  • Genome-wide association studies (GWAS) suggest the Major Histocompatibility Complex (MHC) region's involvement in BD.
  • Inflammatory processes are commonly observed in BD patients.

Purpose of the Study:

  • To investigate the influence of human leukocyte antigen (HLA) variations on Bipolar Disorder (BD) risk.
  • To examine the association between HLA variations and clinical presentations of BD.
  • To explore potential HLA-mediated proinflammatory mechanisms in BD pathogenesis.

Main Methods:

  • Genotyping of classical HLA class I and II loci was performed.
  • Study included 475 BD patients and 195 healthy controls (HC).
  • Statistical analysis was used to identify significant associations.

Main Results:

  • A specific HLA-A*02~B*44~DRB1*07 sub-haplotype was less prevalent in BD patients compared to HC.
  • Certain ancestral haplotypes (57.1 and 8.1) were associated with rapid cycling BD.
  • Specific HLA class II sub-haplotypes correlated with suicidal behaviors and distinct disease onset patterns (hypomanic or psychotic symptoms) in BD.

Conclusions:

  • Findings suggest a role for HLA variations in Bipolar Disorder (BD) susceptibility and clinical heterogeneity.
  • The identified HLA associations support the hypothesis of HLA-mediated proinflammatory processes in BD.
  • These results align with known links between HLA haplotypes and other immune-related disorders.