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Recent advances in models for screening potential osteoporosis drugs
D Merlotti1,2, M Materozzi1, T Picchioni1
1a Department of Medicine, Surgery and Neurosciences , University of Siena, Policlinico Santa Maria alle Scotte , Siena , Italy.
Expert Opinion on Drug Discovery
|June 6, 2018
Summary
Osteoporosis treatments have advanced beyond older methods with new antiresorptive and anabolic drugs. Future osteoporosis drug development requires rigorous long-term studies focusing on bone quality and potential side effects.
Area of Science:
- Bone biology and skeletal aging research.
- Pharmacological development of osteoporosis treatments.
Background:
- Osteoporosis is a growing health and economic concern, particularly in aging populations.
- Recent research has yielded antiresorptive and anabolic bone agents, improving osteoporosis management.
- New therapeutic compounds are under active preclinical and clinical investigation.
Purpose of the Study:
- To review approaches for developing antiresorptive and anabolic agents for osteoporosis.
- To highlight advances in technology and skeletal biology impacting osteoporosis drug discovery.
- To discuss implications for novel osteoporosis drug development.
Main Methods:
- Review of preclinical and clinical development strategies.
- Focus on technological advancements in drug discovery.
- Analysis of current understanding in skeletal biology.
Main Results:
- Approved osteoporosis drugs and compounds in development show improved patient management.
- Long-term nonclinical studies are crucial for new osteoporosis drugs.
- New technologies and models are needed to assess drug effects on skeletal aging and fragility.
Conclusions:
- Rigorous long-term nonclinical studies are essential for new osteoporosis drugs, evaluating bone quality and off-target effects.
- Developing new technologies and models is critical for comprehensive drug screening, assessing effects beyond bone mass.
- Continued research in skeletal biology and technology will drive novel osteoporosis drug discovery.
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