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Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters
Hale Cigdem Arca, Laura I Mosquera-Giraldo1, Vivian Bi2
1Department of Industrial and Physical Pharmacy , Purdue University , West Lafayette , Indiana 47907 , United States.
Biomacromolecules
|June 6, 2018
Summary
Cellulose ethers are versatile natural polymers with significant pharmaceutical value due to their beneficial properties and low toxicity. This review details their structure, properties, and diverse applications in medicine.
Area of Science:
- Polymer Science
- Materials Science
- Pharmaceutical Sciences
Background:
- Cellulose ethers are natural-based polymers with broad industrial applications.
- Their unique properties, including low toxicity and good stability, make them ideal for pharmaceutical use.
- Many cellulose ethers are approved by the U.S. Food and Drug Administration for various applications.
Purpose of the Study:
- To review the pharmaceutical applications of cellulose ethers from a structure-property-function perspective.
- To discuss key commercial cellulose ether classes and their derivatives.
- To summarize their synthesis, material properties, and specific uses in pharmaceuticals.
Main Methods:
- Literature review of pharmaceutical applications of cellulose ethers.
- Analysis of structure-property-function relationships for different cellulose ether types.
- Summary of synthesis methods and material properties.
Main Results:
- Detailed discussion of carboxymethyl cellulose, methyl cellulose, hydroxypropylcellulose, hydroxypropyl methyl cellulose, and ethyl cellulose.
- Exploration of cellulose ether esters like hydroxypropyl methyl cellulose acetate succinate and carboxymethyl cellulose acetate butyrate.
- Highlighting of key pharmaceutical applications driven by specific material properties.
Conclusions:
- Cellulose ethers offer a valuable platform for pharmaceutical development due to their tunable properties and safety profile.
- Understanding the structure-property-function relationships is crucial for optimizing their use in drug delivery and formulation.
- Continued research into novel cellulose ether derivatives and applications holds significant promise for the pharmaceutical industry.
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