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Updated: Feb 9, 2026

Electrowetting-based Digital Microfluidics Platform for Automated Enzyme-linked Immunosorbent Assay
Published on: February 23, 2020
Neonatal screening for four lysosomal storage diseases with a digital microfluidics platform: Initial results in
Eurico Camargo Neto1, Jaqueline Schulte1, Jamile Pereira1
1Centro de Triagem, Porto Alegre, RS, Brazil.
Abstract:
We describe the initial results of a neonatal screening program for four lysosomal storage diseases (MPS I, Pompe, Gaucher and Fabry) using the digital microfluidics methodology. The method successfully identified patients previously diagnosed with these diseases and was used to test dried blood spot samples obtained from 10,527 newborns aged 2 to 14 days. The digital microfluidic technology shows potential for a simple, rapid and high-throughput screening for these four diseases in a standard neonatal screening laboratory.
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