Related Experiment Video

Updated: Feb 9, 2026

Autologous Blood Injection to Model Spontaneous Intracerebral Hemorrhage in Mice
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Autologous Blood Injection to Model Spontaneous Intracerebral Hemorrhage in Mice

Published on: August 24, 2011

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[Administration of idarucizumab in spontaneous intracerebral hemorrhage under dabigatran-therapy]

Dániel Bereczki1,2, Géza Szilágyi1, Ilona Kakuk1

  • 1Magyar Honvédség Egészségügyi Központ, Neurológiai Osztály, Budapest.

Ideggyogyaszati Szemle
|June 6, 2018
PubMed

Introduction - Among antidotes in development for reversal of novel oral anticoagulants, dabigatran-specific idarucizumab was the first one to reach the market. Case presentation - We present the first Hungarian case of intracerebral hemorrhage under treatment with dabigatran, where idarucizumab was administered to suspend anticoagulation. Discussion - Our report is concordant with prior publications, confirming the efficacy of the antidote in reversing the effect of dabigatran, and thus, preventing intracerebral hematoma progression in the acute phase. Conclusion - Since there is no proven alternative to idarucizumab, conducting randomized clinical trials would be unethical. Therefore, besides case reports, positive results of prospective studies could help us revise therapeutic guidelines, and thus, improve the prognosis of dabigatran-associated intracerebral hemorrhages.

Keywords:
dabigatranidarucizumabintracerebral hemorrhage

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