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Updated: Feb 9, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.7K

[Systemic thrombolysis after the administration of idarucizumab in acute ischemic stroke]

Máté Pásztor1, Dániel Bereczki1, Zoltán Szakács1

  • 1Magyar Honvédség Egészségügyi Központ, Neurológiai Osztály, Budapest.

Ideggyogyaszati Szemle
|June 6, 2018
PubMed

Introduction - Expanding indications have resulted in an increasing number of patients taking novel oral anticoagulants, posing a major treatment dilemma in acute ischemic stroke. Case presentation - We present a successful intravenous thrombolysis in a dabigatran-treated patient with acute ischemic stroke after the administration of idarucizumab. Discussion - According to current guidelines, systemic thrombolysis is contraindicated under treatment with novel oral anticoagulants (taken within 48 hours). In this scenario, idarucizumab offers a solution by reversing the anticoagulant effect of dabigatran. Conclusion - Although there have only been case reports published so far, the dabigatran-antidote idarucizumab seems to give new therapeutic opportunities in the treatment of acute ischemic stroke.

Keywords:
alteplaseantidotedabigatranidarucizumabischemic strokesystemic thrombolysis

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