Prostaglandin A2 receptor in rat intestinal basolateral plasma membranes

The specific prostaglandin A2 receptor was presented in rat intestinal basolateral plasma membrane. The dissociation constant was 4.39 X 10(-8) M and the value of the binding capacity was 3.33 pmol/mg protein. [3H]prostaglandin A2 binding was specifically inhibited by Na+ or ATP. The inhibition manners of Na+ and ATP for [3H]prostaglandin A2 binding were of a competitive and noncompetitive type, respectively.