[Review of bisphosphonate related osteonecrosis of the jaws]

The bisphosphonates (BPs) has been widely used as anti-resorptive agents owing to their anti-osteoclatic action. However, patients treated with BPs for a long time may subsequently develop bisphosphonate-related osteonecrosis of the jaws (BRONJ). Now, the exact pathogenesis of the BRONJ is poorly understood. There were also no standard diagnosis and treatment methods for this complication. The maxilla necrosis related to BRONJ can cause maxillary sinusitis, fistula, and sinus tract, which arose more attention from the otolaryngologists. In this article, the pathogenesis, symptoms, and treatments of BRONJ are systemically reviewed. The aim is to deepen the recognition of this complication to otolaryngologists, and to avoid missed diagnosis and misdiagnosis. It is hoped that an early diagnosis and suitable treatments could be provided for a good prognosis in such patients.