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Updated: Feb 9, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
Published on: March 3, 2023
[Expression of serum interleukin 5 and osteopontin in patients with allergic rhinitis]
1Department of Otolaryngology, the Affiliated Hospital of Binzhou Medical University,Binzhou,256603,China.
Abstract:
Objective:To investigate the role of serum IL-5 and osteopontin(OPN) in patients with allergic rhinitis(AR).Method:The levels of serum IL-5 and OPN in 62 treatment naive AR patients were determined using ELISA. The relationships among the expression of serum IL-5, OPN and clinical characteristics were analyzed.Result:Serum OPN and IL-5 in AR patients were significantly higher than those of healthy individuals.Patients with asthma had significantly higher OPN and IL-5 than that of patients without asthma.OPN in AR patients was positively correlated with TNSS and total IgE, but not blood eosinophil count. IL-5 was positively correlated with TNSS, total IgE and blood eosinophil count.OPN is positively correlated with IL-5.Conclusion:Both OPN and IL-5 are involved in the pathogenesis of AR.Serum OPN and IL-5 can be useful biomarkers for evaluating the severity of AR.
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