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A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
[Association of CTLA-4 gene polymorphism in allergic rhinitis with asthma or not in children]
1Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University,Chongqing,400016,China.
Abstract:
Objective:To evaluate the involvement of the cytotoxic T lymphocyte associated antigen (CTLA-4) gene polymorphisms in susceptibility of allergic rhinitis(AR) with/without asthma in children.Method:Three hundred and two AR children,288 AR with asthma children,and 327 healthy Chinese Han children were enrolled in the study.The SNPs of CTLA-4(rs3087243,rs11571302,rs11571315,rs231725,rs35219727,and rs4553808) were sequenced using a PCR restriction fragment length polymorphism assay.Result: An increased frequency of the AA genotype and A allele in rs3087243 of CTLA-4 was found in AR with asthma group.For rs231725,AA genotype and A allele were obviously increased in AR group, while they were significantly decreased in AR with asthma group(P<0.05).Conclusion:We found a significant association between CTLA-4 gene polymorphism and AR with asthma in Chinese Han children, which might be an autoimmunity risk factor for AR with asthma.
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