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Updated: Feb 9, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
[Analysis and treatment of postoperative blockage of tympanic ventilation tubes]
1Department of Otolaryngology-Head and Neck Surgery,Eye and ENT Hospital,Fudan University;Key Laboratory of Hearing Medicine,National Health and Family Planning Commission;Shanghai Clinical Medical Center of Hearing Medicine,Shanghai,200031,China.
Abstract:
Objective:To explore the occurrence and treatment of complications of postoperative blockage of tympanic ventilation tubes.Method:Two hundred and four patients(278 ears)with otitis media with effusion(OME) who received tympanostomy tube insertion from February 2010 to February 2016 were retrospectively analyzed.Ofloxacin ear drops was introduced into 80 ears in 59 patients undergoing myringotomy and ventilation tube insertion. In a follow-up period of 1,3,6,12 months,if the blockage is caused by viscid secretion,blood clot or cerumen,4% of sodium bicarbonate ear drops were used to treat patients. 3% aquae hydrogenii dioxidi and Ofloxacin ear drops were used on the patients with purulent otorrhea.Result:In the 198 ears without Ofloxacin ear drops treatment,postoperative tube obstruction occurred in 16 ears(8 of viscid secretion,3 of blood clot,3 of cerumen and 2 of purulent otorrhea). Of the 59 patients who received Ofloxacin ear drops treatment,seven ears experienced blocked tubes(1 of viscid secretion,1 of blood clot,4 of cerumen and 1 of purulent otorrhea).Conclusion:The complication of postoperative blockage of tympanic ventilation tubes is common. Relative prevention and therapy should be performed during intraoperative and postoperative procedures. Short term treatment of Ofloxacin ear drops can prevent postoperative blockage of tympanic ventilation tubes and infection.
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