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The Roles of MicroRNAs in Stroke: Possible Therapeutic Targets

Weilin Xu1, Liansheng Gao1, Jingwei Zheng1

  • 11 Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Cell Transplantation
|June 7, 2018
PubMed

Insights

MicroRNAs (miRNAs) play a crucial role in stroke pathophysiology, impacting processes like apoptosis and neuroinflammation. Understanding the stroke-miRNA connection offers potential for new therapeutic and diagnostic strategies.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biomedical Research

Background:

  • Stroke is a leading global cause of disability and mortality.
  • MicroRNAs (miRNAs) have emerged as critical regulators in various biological processes.
  • Emerging evidence links miRNA expression to stroke outcomes and progression.

Purpose of the Study:

  • To review and synthesize current research on the intricate relationship between miRNAs and stroke.
  • To elucidate the role of miRNAs in the complex pathophysiology of stroke.
  • To highlight the potential of miRNA-based approaches for stroke treatment.

Main Methods:

  • Comprehensive literature review of studies investigating miRNAs and stroke.
  • Analysis of miRNA involvement in key post-stroke pathological mechanisms.
  • Synthesis of findings related to miRNA expression and stroke prognosis.

Main Results:

  • miRNAs are extensively involved in post-stroke pathophysiology, including apoptosis, neuroinflammation, oxidative stress, blood-brain barrier disruption, and brain edema.
  • Specific miRNA expression patterns are associated with stroke prognosis.
  • The complex interplay between miRNAs and stroke mechanisms is increasingly understood.

Conclusions:

  • MicroRNAs are significant players in the cellular and molecular events following a stroke.
  • Targeting the stroke-miRNA system holds promise for developing novel therapeutic interventions.
  • Further research into miRNA biomarkers could enhance diagnostic capabilities for stroke management.
Keywords:
cerebral ischemiaintracerebral hemorrhagemicroRNAstrokesubarachnoid hemorrhage

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