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Cytochrome P450 research and The Journal of Biological Chemistry

F Peter Guengerich1

  • 1Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.

The Journal of Biological Chemistry
|June 7, 2018
PubMed

Insights

This review highlights the Journal of Biological Chemistry's (JBC) significant contributions to cytochrome P450 (P450) research, tracing its coverage from early discoveries to modern advancements in enzyme characterization.

Area of Science:

  • Biochemistry
  • Enzymology

Background:

  • The Journal of Biological Chemistry (JBC) has a long history of publishing research on enzymes, including those involved in drug metabolism and detoxification.
  • Cytochrome P450 enzymes, initially recognized by their unique spectral properties, play critical roles in various biological processes.

Observation:

  • JBC published foundational studies on cytochrome P450 (P450) enzymes even before their identity was established.
  • The journal documented the discovery of the P450 pigment in 1962 and subsequent methodological advancements.

Findings:

  • JBC has consistently been a leading venue for P450 research, publishing seminal findings on enzyme activity, structure, mechanisms, and regulation.
  • The journal's extensive coverage reflects the significant growth and evolution of the P450 field over decades.

Implications:

  • The comprehensive publication record in JBC underscores its pivotal role in advancing the understanding of P450 biochemistry.
  • This historical overview celebrates the journal's impact and acknowledges Dr. Herbert Tabor's contributions as Editor-in-Chief.

Keywords:
cytochrome P450eicosanoidendoplasmic reticulum (ER)mitochondriaretinoidsteroid

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