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Updated: Feb 9, 2026

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Published on: March 20, 2020
Histopathology findings of non-mass cancers on breast ultrasound
Hye Rin Kim1, Hae Kyoung Jung2
1Department of Radiology, CHA Gangnam Medical Center, CHA University, Seoul, Republic of Korea.
Background:
There is little research done on non-mass cancers (NMCs) on breast ultrasound (US).
Purpose:
To evaluate large-sectional histopathology findings of NMCs on breast US.
Material And Methods:
The mammographic and histopathology features of biopsy proven 36 breast cancers which showed pure non-mass lesions on US were retrospectively reviewed.
Results:
The most common mammographic finding was microcalcification (23/35, 65.7%); fine pleomorphic microcalcification was predominant (18/23, 78.3%). The main tumor type was pure ductal carcinoma in situ (DCIS) (14/36, 38.9%) and DCIS with micro- or minimal invasion (11/36, 30.6%). Among the 25 DCIS, histologic grade was high in 15 (60.0%) and intermediate in nine (36%); comedo necrosis was seen in 17 (68%). Immunohistochemical analysis was available in 27 lesions and showed HER2-overexpression in 12 (44.4%) and triple-negative in two (7.4%).
Conclusion:
According to our limited patient sample, NMCs on breast US were mainly associated with high-grade DCIS.
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