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Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
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Biomimetic nanoparticles for inflammation targeting.

Kai Jin1, Zimiao Luo1,2, Bo Zhang1

  • 1School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China.

Acta Pharmaceutica Sinica. B
|June 7, 2018
PubMed
Summary

Biomimetic nanoparticles that mimic immune cells offer new ways to diagnose and treat inflammatory diseases. This review explores their design for improved molecular imaging and targeted drug delivery to inflammatory sites.

Keywords:
Biomimetic nanoparticlesCAM, cellular adhesion moleculeCCL5, chemokine (C-C motif) ligand 5CD40L, cluster of differentiation 40 ligandCTC, circulating tumor cellCTL, cytotoxic T cell or CD8+ T cellCXCL4, chemokine (C-X-C motif) ligand 4CXCR1, chemokine (C-X-C motif) receptor 1Cell membraneCell membrane proteinsCy7, cyanine 7DC, dendritic cellDSPE-PEG, distearoyl Phosphoethanolamine-poly(ethylene glycol)GPIV, glycoprotein IVGPIX, glycoprotein IXGPIbα, glycoprotein IbαGPV, glycoprotein VGPVI, glycoprotein VIHUVEC, umbilical cord vascular endothelial cellIBD, inflammatory bowel diseaseICAM-1, intercellular cellular adhesion molecule-1IL, interleukinIgG, immunoglobulin GImmune cellsInflammation targetingLFA-1, lymphocyte function associated antigen-1LLV, leukocyte-like vectorLPS, lipopolysaccharideMHC, major histocompatibility complexMRI, magnetic resonance imagingMac-1, macrophage adhesion molecule-1Molecular imagingNM-NP, neutrophil membrane-coated nanoparticlePECAM-1, platelet-endothelial cellular adhesion molecule-1PLA-PEG, poly(lactic acid)-poly(ethylene glycol)PLGA, poly(lactic-co-glycolic acid)PNP, platelet membrane-cloaked nanoparticlePSGL-1, P-selectin glycoprotein ligand-1RA, rheumatoid arthritisRBC, red blood cellSLeX, sialyl lewis XSPIO, super paramagnetic iron oxideTGF-β, transforming growth factor βTNF-α, tumor necrosis factor-αTargeting ligandsTh cell, T-helper cell or CD4+ T cellVCAM-1, vascular cellular adhesion molecule-1VLA-4, very late antigen-4VWF, Von Willebrand factorapoE–/– mice, Apolipoprotein e knockout mice

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Immunology

Background:

  • Inflammation is a key factor in many human diseases.
  • Biomimetic nanoparticles can be designed to target inflammatory sites.
  • Mimicking immune cells enhances nanoparticle function.

Purpose of the Study:

  • To review inflammation-targeting biomimetic nanoparticles.
  • To explore nanoparticle design strategies for disease diagnosis and treatment.
  • To highlight advancements in using biomimetic nanoparticles for inflammation.

Main Methods:

  • Literature review of recent developments in biomimetic nanoparticles.
  • Analysis of nanoparticle design principles for targeting inflammation.
  • Discussion of applications in molecular imaging and drug delivery.

Main Results:

  • Biomimetic nanoparticles show promise for precise targeting of inflammatory conditions.
  • Design strategies focus on mimicking immune cell functions.
  • These nanoparticles facilitate both diagnostic imaging and therapeutic delivery.

Conclusions:

  • Biomimetic nanoparticles represent a significant advancement in managing inflammatory diseases.
  • Optimized design is crucial for maximizing diagnostic and therapeutic efficacy.
  • Further research holds potential for novel disease treatments.