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Updated: Feb 9, 2026
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Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
Published on: January 7, 2019
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Precision cancer therapy is impacted by oncogene-dependent epigenome remodeling
Feng Liu1, Paul S Mischel2,3,4, Webster K Cavenee2,4,5
11National Research Center for Translational Medicine (Shanghai), State Key Laboratory of Medical Genomics, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 China.
NPJ Precision Oncology
|June 7, 2018
Summary
Understanding cancer
Area of Science:
- Oncology
- Genomics
- Epigenetics
Background:
- Cancer genome analysis identifies oncogenic drivers for targeted therapies.
- Oncogenes can alter the epigenome, leading to tumor heterogeneity.
- This epigenetic plasticity presents challenges for effective cancer treatment.
Purpose of the Study:
- To explore the role of epigenome reprogramming by oncogenes.
- To identify actionable vulnerabilities within the epigenome for cancer therapy.
- To broaden the scope of precision oncology.
Main Methods:
- Molecular dissection of the cancer epigenome.
- Analysis of oncogene-induced epigenetic modifications.
- Identification of therapeutic vulnerabilities.
Main Results:
- Oncogenes significantly reprogram the epigenome.
- Epigenetic alterations contribute to cancer heterogeneity.
- Specific epigenetic vulnerabilities can be targeted.
Conclusions:
- The epigenome is a critical layer of complexity in cancer.
- Targeting oncogene-induced epigenetic vulnerabilities can enhance precision oncology.
- Further molecular dissection of the epigenome may reveal new therapeutic strategies.
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