Correction to: Melatonin as an alternative sedation method during magnetic resonance imaging in preschool children with musculoskeletal problems
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Updated: Feb 9, 2026

Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging
Published on: June 5, 2017
Agneza Marija Pasini1, Josip Marjanović2, Goran Roić1
1Children's Hospital Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia.
Insights
Oral melatonin offers a safe, effective, and inexpensive alternative to sedation for preschool children undergoing musculoskeletal magnetic resonance imaging (MRI). This method successfully prevents motion artifacts, improving diagnostic image quality without adverse events.
Area of Science:
- Pediatric Radiology
- Pharmacology
Background:
- Magnetic resonance imaging (MRI) is crucial for diagnosing juvenile idiopathic arthritis but often requires sedation or general anesthesia (GA) in preschool children due to motion artifacts.
- Sedation/GA carries risks, including cardiopulmonary complications, and necessitates skilled personnel.
Purpose of the Study:
- To evaluate oral melatonin as a safe and effective alternative sedation method for preschool children undergoing musculoskeletal MRI.
- To assess the efficacy of melatonin in preventing motion artifacts in pediatric MRI examinations.
Main Methods:
- Fifteen preschool children with suspected juvenile idiopathic arthritis received 10 mg of oral melatonin before their musculoskeletal MRI.
- Image quality was assessed for motion artifacts, and adverse events were monitored.
Main Results:
- Satisfactory MRI images were obtained in 15 out of 16 examinations (93.75%).
- No adverse events were reported following oral melatonin administration.
- Melatonin proved effective in preventing motion artifacts, even without prior sleep deprivation.
Conclusions:
- Oral melatonin is a safe, effective, and inexpensive alternative to sedation/GA for musculoskeletal MRI in preschool children.
- Melatonin can reduce the need for sedation/GA, minimizing associated risks and resource requirements.
Abstract:
AbstractMagnetic resonance imaging (MRI) in preschool children is often challenging due to excessive motion artifacts. Sedation or general anesthesia (GA) are commonly used to prevent children from moving in the MRI scanner, with increased risk for cardiopulmonary complications and requirement for skilled personnel. Herein we investigated whether oral melatonin, a natural hormone implicated in circadian rhythm regulation, could be used as an alternative sedation method prior to the MRI in preschool children with musculoskeletal problems. Fifteen children with suspected juvenile idiopathic arthritis underwent a total of 16 MRI examinations following administration of 10 mg of oral melatonin; satisfactory images were obtained in all but one case, with no adverse events.Conclusion: The use of melatonin before the musculoskeletal MRI in preschool children is an effective, safe and inexpensive alternative to standard sedation and general anesthesia in preventing motion artifacts. What is known: • Magnetic resonance imaging (MRI) is a well-recognized diagnostic method to visualize synovial inflammation and changes of cartilage and bone in juvenile idiopathic arthritis.• MRI examination requires sedation or general anesthesia to ensure immobility in children who are uncooperative. What is new: • Additional to previous published studies we were able to show that melatonin for sedation for an MRI of joints, even without sleep deprivation, in the studied population may provide an alternative in children without behavioral problems, in order to avoid sedation/GA.
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