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The effect of Helicobacter pylori eradication on functional dyspepsia in Turkish children

Aysel Ünlüsoy Aksu1, Güldal Yılmaz2, Ödül Eğritaş Gürkan1

  • 1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Gazi University Faculty of Medicine, Ankara, Turkey.

Helicobacter
|June 7, 2018
PubMed

Insights

Helicobacter pylori (H. pylori) eradication therapy significantly reduced dyspepsia symptoms in children with functional dyspepsia. Eradication improved scores more than in non-eradicated cases, especially in high-prevalence settings.

Area of Science:

  • Pediatric Gastroenterology
  • Microbiology
  • Clinical Medicine

Background:

  • Functional dyspepsia (FD) is common in children.
  • Helicobacter pylori (H. pylori) infection is a potential contributor to FD.
  • Evaluating H. pylori eradication's impact on pediatric FD is crucial.

Purpose of the Study:

  • To assess the effect of H. pylori eradication on dyspepsia symptom scores in pediatric FD patients.
  • To compare symptom improvement between H. pylori-eradicated and non-eradicated groups.

Main Methods:

  • Prospective study of 150 children (8-18 years) with FD.
  • H. pylori diagnosis via endoscopy and 13C-urea breath test.
  • Symptom assessment at baseline, 8 weeks, and 16 weeks post-treatment.

Main Results:

  • 33% of children tested positive for H. pylori.
  • Dyspepsia scores improved in both H. pylori-positive and negative groups by 8 weeks.
  • H. pylori eradication (61% success) led to significant symptom score reduction compared to the non-eradicated group.

Conclusions:

  • H. pylori eradication therapy effectively decreases dyspepsia symptoms in children with FD, particularly in high-prevalence areas.
  • While diagnostic tests add cost, symptom improvement justifies H. pylori screening in endemic regions.
  • Findings may vary in low-prevalence settings; H. pylori testing is generally not recommended without alarm symptoms in such cases.
Abstract

Keywords:
Helicobacter pylori eradicationchildrenfunctional dyspepsia

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