Related Experiment Video
Updated: Feb 9, 2026

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
Published on: September 13, 2024
Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives
Luiz C S Pinheiro1, Lívia M Feitosa1, Flávia F DA Silveira1
1Departamento de Síntese de Fármacos, Instituto de Tecnologia em Fármacos Farmanguinhos, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
Abstract:
According to the World Health Organization, malaria remains one of the biggest public health problems in the world. The development of resistance is a current concern, mainly because the number of safe drugs for this disease is limited. Artemisinin-based combination therapy is recommended by the World Health Organization to prevent or delay the onset of resistance. Thus, the need to obtain new drugs makes artemisinin the most widely used scaffold to obtain synthetic compounds. This review describes the drugs based on artemisinin and its derivatives, including hybrid derivatives and dimers, trimers and tetramers that contain an endoperoxide bridge. This class of compounds is of extreme importance for the discovery of new drugs to treat malaria.
Related Concept Videos
Synthetic Biology
Golden rice
Golden rice is a genetically modified...
Synthetic Disvision of Polynomials
Gene Therapy
Electrical Current
Overview of Advanced Functional Groups
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
Extraction: Advanced Methods

