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Updated: Feb 9, 2026

Single-Cell Calcium Imaging for Studying the Activation of Calcium Ion Channels
Published on: December 13, 2024
Calcium signalling and related ion channels in neutrophil recruitment and function
Roland Immler1, Scott I Simon2, Markus Sperandio1
1Walter Brendel Centre of Experimental Medicine, Biomedical Center, Ludwig-Maximilians-Universität München, Munich, Germany.
Abstract:
The recruitment of neutrophils to sites of inflammation, their battle against invading microorganisms through phagocytosis and the release of antimicrobial agents is a highly coordinated and tightly regulated process that involves the interplay of many different receptors, ion channels and signalling pathways. Changes in intracellular calcium levels, caused by cytosolic Ca2+ store depletion and the influx of extracellular Ca2+ via ion channels, play a critical role in synchronizing neutrophil activation and function. In this review, we provide an overview of how Ca2+ signalling is initiated in neutrophils and how changes in intracellular Ca2+ levels modulate neutrophil function.
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