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Updated: Feb 9, 2026

Ultrasonic Assessment of Myocardial Microstructure
Published on: January 14, 2014
Can myocardial remodeling be a useful surrogate predictor of myocardial iron load? A 3D echocardiographic
Hala Mounir Agha1, Antoine Fakhry AbdelMassih1,2, Mohamed Youssef AbdelRahman1
1Pediatric, Cardiology Unit, Pediatrics Department, Specialized Children Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt.
Abstract:
The relationship between myocardial iron load and eccentric myocardial remodeling remains an under-investigated area; it was thought that remodeling is rather linked to fibrosis. This study aims to determine whether or not measures of remodeling can be used as predictors of myocardial iron. For this purpose, 60 patients with thalassemia were studied with 3D echocardiography and myocardial relaxometry (T2*) by Cardiac MRI. 3D derived sphericity index was significantly higher in patients with myocardial iron load. It was correlated with T2* with a 100% sensitivity and specificity (cut-off value of 0.34) to discriminate between patients with and without myocardial iron overload.
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