Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

2.0K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K
Cancer02:18

Cancer

54.4K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.4K
What is Cancer?02:12

What is Cancer?

14.5K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.5K
Cancer Prevention02:59

Cancer Prevention

8.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.2K
Cancer Therapies02:49

Cancer Therapies

10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Cancer Vaccines01:30

Cancer Vaccines

1.1K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

3D printed nano-hydroxyapatite scaffold combined with BMSCs cell sheet containing concentrated growth factor (CGF) for enhancing bone regeneration.

Stem cell research & therapy·2026
Same author

Subthreshold Thermal Stress Aggravates Methamphetamine-Induced Cardiomyocyte Pyroptosis via the Mitochondrial ROS/BAX/mtDNA/NLRP3 Pathway.

International journal of molecular sciences·2026
Same author

Parametric Modal Regression With Error Contaminated Covariates.

Biometrical journal. Biometrische Zeitschrift·2026
Same author

Aurka-Bhlhe41 axis prevents premature aging-like microglial dysfunction and promotes remyelination.

Nature communications·2026
Same author

Mask-Aware Spatiotemporal Classification of Millimeter-Wave Radar Point Cloud Sequences Using DGCNN and Transformer for Child-Pet Recognition in Enclosed Spaces.

Sensors (Basel, Switzerland)·2026
Same author

β-Asarone Mediates the Alleviation of Neuroinflammation in Alzheimer's Disease Via Modulation of the TREM2/PI3K/AKT Signaling Pathway.

Inflammation·2026

Related Experiment Video

Updated: Feb 9, 2026

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
11:34

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

13.1K

HER2-Based Immunotherapy for Breast Cancer.

Naipeng Cui1, Jianhong Shi2, Chuanwei Yang3

  • 11 Department of Breast Surgery, Affiliated Hospital of Hebei University , Baoding, China .

Cancer Biotherapy & Radiopharmaceuticals
|June 7, 2018
PubMed
Summary
This summary is machine-generated.

Human epidermal growth factor receptor 2 (HER2)-targeted peptide vaccines show promise for breast cancer treatment, offering an active immunotherapy approach. This review analyzes clinical trials of HER2 peptide vaccines, including combination therapies.

Keywords:
HER2breast cancerimmunotherapypeptide vaccine

More Related Videos

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

18.9K
Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

7.1K

Related Experiment Videos

Last Updated: Feb 9, 2026

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
11:34

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

13.1K
Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

18.9K
Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

7.1K

Area of Science:

  • Oncology
  • Immunotherapy
  • Vaccine Development

Background:

  • Breast cancer treatment faces challenges with therapy resistance and recurrence.
  • Active immunotherapy with human epidermal growth factor receptor 2 (HER2)-targeted vaccines is a promising strategy.
  • Various HER2-derived vaccines have been developed and tested.

Purpose of the Study:

  • To review and analyze clinical trials of HER2-based vaccines over the past 20 years.
  • To focus on trials utilizing HER2 peptide vaccines.
  • To present findings on combination therapies involving HER2 peptide vaccines.

Main Methods:

  • Literature review of published clinical trials on HER2 vaccines.
  • Focus on trials conducted within the last two decades.
  • Inclusion of trials evaluating HER2 peptide vaccines and combination therapies.

Main Results:

  • HER2 peptide vaccines have been extensively studied in clinical trials.
  • Combination therapies involving HER2 peptide vaccines show potential.
  • The review synthesizes data from major HER2 vaccine trials.

Conclusions:

  • HER2 peptide vaccines represent a significant area of research in breast cancer immunotherapy.
  • Further investigation into combination strategies may enhance treatment efficacy.
  • Clinical trial data supports the ongoing development of HER2-targeted vaccines.