Related Experiment Video
Updated: Feb 9, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
20.9K
The contemporary management of systemic sclerosis
Maysoon Eldoma1,2,3, Janet Pope1,4
1a Division of Rheumatology, St. Joseph's Health Care, Department of Medicine , University of Western Ontario , Ontario , Canada.
Expert Review of Clinical Immunology
|June 7, 2018
Summary
Systemic sclerosis (SSc) treatments offer modest improvements by targeting affected organs. Future strategies may involve combination therapies and personalized approaches to improve efficacy and reduce mortality in SSc patients.
Area of Science:
- Rheumatology
- Immunology
- Internal Medicine
Background:
- Systemic sclerosis (SSc) is a rare autoimmune disease with complex pathophysiology, leading to organ damage despite current treatments.
- Vascular dysfunction, fibrosis, inflammation, and autoantibodies are key features of SSc.
- Existing therapies provide only modest improvements, highlighting the need for advanced treatment strategies.
Purpose of the Study:
- To review current treatment strategies for Systemic Sclerosis (SSc) across various affected organs.
- To outline an evidence-based approach to SSc treatment tailored to disease manifestations.
- To discuss future directions for improving SSc treatment efficacy and patient outcomes.
Main Methods:
- Literature review of treatment strategies for SSc.
- Evaluation of therapies based on organ involvement (skin, pulmonary, cardiac, renal, musculoskeletal, gastrointestinal).
- Analysis of current evidence and expert commentary on SSc management.
Main Results:
- Pulmonary hypertension and interstitial lung disease are the leading causes of mortality in SSc.
- Current treatments often adapt therapies from other conditions, such as idiopathic pulmonary arterial hypertension treatments for vascular manifestations.
- Treatment efficacy is modest, with significant unmet needs in managing SSc.
Conclusions:
- SSc management requires a multi-organ approach, with pulmonary and interstitial lung disease being critical concerns.
- Future SSc treatment may involve combination and maintenance therapies, similar to other autoimmune diseases.
- Personalizing treatment based on patient phenotype is crucial for enhancing efficacy and reducing SSc-related mortality.
Related Concept Videos
01:29Contemporary Psychology
2.3K
Psychology explores human behavior and mental processes through various lenses, each offering unique insights. This overview examines key subfields, including biopsychology, evolutionary, developmental, personality, and social psychology, highlighting their approaches and contributions to understanding complex human behaviors.
Biopsychology
Biopsychology, also known as biological psychology or behavioral neuroscience, focuses on the biological underpinnings of behavior and mental processes. It...
Biopsychology
Biopsychology, also known as biological psychology or behavioral neuroscience, focuses on the biological underpinnings of behavior and mental processes. It...
2.3K
01:18Second Order systems II
412
In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
412
01:21First Order Systems
433
First-order systems, such as RC circuits, are foundational in understanding dynamic systems due to their straightforward input-output relationship. Analyzing their responses to different input functions under zero initial conditions reveals significant insights into system behavior.
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
433
01:20Second Order systems I
603
A servo system exemplifies a second-order system, featuring a proportional controller and load elements that ensure the output position aligns with the input position. The relationship between these components is described by a second-order differential equation. Applying the Laplace transform under zero initial conditions yields the transfer function, showing how inputs are converted to outputs in the system.
By reinterpreting the system, one can derive the closed-loop transfer function, which...
By reinterpreting the system, one can derive the closed-loop transfer function, which...
603
01:06Thermodynamic Systems
8.2K
A thermodynamic system is a set of objects whose thermodynamic properties are of interest. The system is considered to be embedded in its surroundings or the environment. The system and its environment can exchange heat and do work on each other through a boundary that separates them. However, the immediate surroundings of the system interact with it directly and therefore have a much stronger influence on its behavior and properties.
Consider an example of tea boiling in a kettle. The...
Consider an example of tea boiling in a kettle. The...
8.2K
01:26Classification of Systems-I
596
Linearity is a system property characterized by a direct input-output relationship, combining homogeneity and additivity.
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:
596