Fluoride Penetration and Clearance Are Higher in Exopolysaccharide-Containing Bacterial Pellets
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Updated: Feb 9, 2026

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
Published on: February 23, 2024
Manuela S Spinola1, Diego Figueiredo Nóbrega1, Altair Antoninha Del Bel Cury1
1Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Abstract:
Extracellular polysaccharides (EPS) could increase the penetration of fluoride through dental biofilm, reducing its cariogenicity. We measured the concentration of fluoride in EPS-containing (EPS+) or not-containing (EPS-) Streptococcus mutans bacterial pellets resembling test biofilms, before and up to 60 min after a 0.05% NaF rinse in situ. Fluoride penetration and clearance were higher in EPS+ bacterial pellets. The data suggest that EPS enhances fluoride penetration, but also accelerates fluoride clearance from dental biofilms.
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