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Related Experiment Video

Updated: Feb 9, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
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Iron Promotes Intestinal Development in Neonatal Piglets.

Yutian Pu1, Shuhui Li2, Haitao Xiong3,4

  • 1Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, College of Animal Science, Zhejiang University, Hangzhou 310058, China. pyt0830@126.com.

Nutrients
|June 8, 2018
PubMed
Summary

Iron supplementation in piglets promotes gut development and immunity. This study shows iron dextran (FeDex) improves intestinal morphology and immune function, crucial for early nutrition.

Keywords:
cytokineimmunityintestineironneonatal

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Area of Science:

  • Animal models
  • Gastroenterology
  • Immunology

Background:

  • Early nutrition is critical for gut and immune system development.
  • The impact of iron supplementation on gut development requires further investigation.
  • Iron deficiency anemia is a recognized health concern.

Purpose of the Study:

  • To assess the effects of iron supplementation on hematological status, gut development, and immunity in piglets.
  • To elucidate the role of iron dextran (FeDex) in promoting intestinal health.
  • To understand iron's influence on the developing immune system.

Main Methods:

  • Suckling piglets were used as a model for iron deficiency.
  • Iron dextran (FeDex) was administered intramuscularly on day three post-birth.
  • Piglets were analyzed at various time points (days 2, 5, 10, and 20) for hematological, gut morphology, and immune parameters.

Main Results:

  • FeDex supplementation improved iron status, evidenced by increased serum iron, ferritin, transferrin, and liver iron loading.
  • Iron supplementation enhanced intestinal morphology, increasing villus length and crypt depth, and improving duodenal health.
  • FeDex modulated intestinal immunity by stimulating cytokine production and enhancing monocyte phagocytic capacity.

Conclusions:

  • Iron supplementation, specifically with FeDex, promotes intestinal development by improving morphology and mucosal integrity.
  • Iron plays a vital role in enhancing intestinal immune factors and overall gut health in early life.
  • This study highlights the benefits of iron supplementation for gut development and immune education in suckling piglets.