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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
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Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
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Adherence to thyroid hormone replacement therapy: a retrospective, claims database analysis.

Zsolt Hepp1, Kathleen Wyne2, Shivaji R Manthena3

  • 1a Formerly Global Health Economics and Outcomes Research Analytics , AbbVie, Inc. , North Chicago , IL , USA.

Current Medical Research and Opinion
|June 8, 2018
PubMed
Summary

Patient adherence to levothyroxine medication for hypothyroidism varies by formulation. Synthroid showed higher adherence rates at 6 and 12 months compared to generic levothyroxine and other brands.

Keywords:
Medication adherencehypothyroidismthyroxine

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Area of Science:

  • Endocrinology
  • Pharmacoeconomics
  • Real-world evidence

Background:

  • Levothyroxine is a critical treatment for hypothyroidism.
  • Patient adherence significantly impacts treatment outcomes.
  • Understanding adherence across different levothyroxine formulations is essential for optimizing patient care.

Purpose of the Study:

  • To compare medication adherence at 6 and 12 months among different levothyroxine formulations.
  • To identify potential differences in adherence rates across generic levothyroxine, Levoxyl, Synthroid, Unithroid, and Tirosint.

Main Methods:

  • Retrospective analysis of insurance claims data from a large, commercially insured population (2000-2016).
  • Inclusion of adult patients diagnosed with hypothyroidism initiating treatment with specific levothyroxine formulations.
  • Adherence defined as proportion of days covered (PDC) ≥ 80%, analyzed using multivariable models.

Main Results:

  • Over 580,000 patients were included in the analysis.
  • Non-adherence rates were 40.3% at 6 months and 51.9% at 12 months.
  • Synthroid demonstrated significantly higher adherence compared to all other formulations at both time points. Tirosint and Unithroid showed lower adherence than generic levothyroxine at 12 months.

Conclusions:

  • Levothyroxine adherence is a significant issue for patients with hypothyroidism.
  • Formulation choice may influence patient adherence rates.
  • Synthroid appears to be associated with better adherence compared to other levothyroxine options.