Related Experiment Video

Updated: Feb 9, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

8.9K

Transcriptional regulation of the cardiac conduction system

Vincent W W van Eif1, Harsha D Devalla1,2, Gerard J J Boink1,2

  • 1Department of Medical Biology, Amsterdam Cardiovascular Sciences, Academic Medical Center, Amsterdam, Netherlands.

Nature Reviews. Cardiology
|June 8, 2018
PubMed

Insights

The cardiac conduction system (CCS) coordinates heartbeats using specialized tissues. This review explores transcriptional networks crucial for CCS development and function, offering insights for new therapies.

Area of Science:

  • Cardiology
  • Developmental Biology
  • Molecular Biology

Background:

  • The cardiac conduction system (CCS) regulates heart rate and rhythm through specialized tissues.
  • CCS function is conserved across vertebrates, with unique features in endotherms.
  • CCS development and homeostasis depend on complex transcriptional and regulatory networks.

Purpose of the Study:

  • To review emerging data on transcriptional networks governing cardiac conduction system formation and function.
  • To discuss the application of these insights for developing disease models and therapies.

Main Methods:

  • Review of animal studies.
  • Analysis of stem cell models.
  • Examination of genome-wide association studies.

Main Results:

  • Novel insights into the transcriptional networks underlying CCS development and function.
  • Understanding of stage-dependent, tissue-dependent, and dose-dependent regulatory mechanisms.
  • Identification of conserved and specialized aspects of CCS function.

Conclusions:

  • Transcriptional networks are fundamental to cardiac conduction system formation and function.
  • Emerging data provide a basis for developing novel therapeutic strategies for cardiac conduction disorders.
  • Further research integrating animal models, stem cells, and genetic studies will advance CCS understanding.

More Related Videos

Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice08:15

Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice

Published on: September 17, 2015

20.0K
Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

8.6K

Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.8K
Master Transcription Regulators02:23

Master Transcription Regulators

2.8K
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
7.4K
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

2.6K
Transcriptional Regulation: Riboswitches01:23

Transcriptional Regulation: Riboswitches

Riboswitches are RNA elements that regulate gene expression by altering their secondary structures in response to specific effector molecules. These elements, located in the leader regions of certain mRNAs, act as transcriptional regulators by toggling between alternative conformations to control downstream gene expression. Riboswitch-mediated regulation is a precise mechanism for modulating biosynthetic pathways, as exemplified by the riboflavin biosynthesis pathway in Bacillus...
723
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.8K