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Related Concept Videos

Ethical Issues01:27

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Socioemotional Experience and Gender Development01:30

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Related Experiment Video

Updated: Feb 9, 2026

Skeletal Muscle Gender Dimorphism from Proteomics
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Gender differences in bronchiectasis: a real issue?

Celine Vidaillac1, Valerie F L Yong1, Tavleen K Jaggi1

  • 1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

Breathe (Sheffield, England)
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Summary

Gender significantly impacts chronic lung diseases like cystic fibrosis (CF) and bronchiectasis, affecting prevalence, severity, and outcomes. Understanding these sex-based differences is crucial for developing targeted treatments to improve patient care.

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Area of Science:

  • Pulmonary Medicine
  • Medical Research
  • Epidemiology

Background:

  • Chronic respiratory diseases, including cystic fibrosis (CF) and non-CF bronchiectasis, exhibit clear gender-specific differences in prevalence, severity, and outcomes.
  • The underlying mechanisms driving these sex-based disparities in lung diseases remain poorly understood due to a lack of dedicated research.

Purpose of the Study:

  • To review existing epidemiological, biological, and environmental evidence on gender differences in bronchiectasis.
  • To identify key areas for gender-tailored interventions in the diagnosis, monitoring, and treatment of bronchiectasis.

Main Methods:

  • Systematic review of epidemiological, biological, and environmental data.
  • Analysis of factors influencing gender disparities in CF and non-CF bronchiectasis.

Main Results:

  • Gender influences the prevalence, clinical presentation, and severity of CF and non-CF bronchiectasis.
  • Microbiology and host physiology, including immune and inflammatory responses, are key factors affected by gender.
  • Sex steroid hormones play a potential role in the gender-specific differences observed in bronchiectasis.

Conclusions:

  • Gender is a significant factor in the complexity of chronic pulmonary diseases like bronchiectasis.
  • Targeted, gender-focused clinical and therapeutic interventions hold promise for reducing the gender gap in bronchiectasis outcomes.
  • Further research into the interplay of microbiology, host physiology, and environmental factors is essential for a comprehensive understanding.