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'Boden Food Plate': Novel Interactive Web-based Method for the Assessment of Dietary Intake
Published on: September 18, 2018
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Dietary cholesterol intake and stroke risk: a meta-analysis
Pengfei Cheng1,2,3,4, Junxi Pan2,3,5, Jinjun Xia2,3,5
1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Oncotarget
|June 8, 2018
Summary
Dietary cholesterol intake does not appear to increase overall stroke risk. However, higher cholesterol consumption may elevate stroke risk in older females with a higher body mass index.
Area of Science:
- Nutrition Science
- Epidemiology
- Cardiovascular Health
Background:
- The link between dietary cholesterol and stroke risk is a long-standing area of debate.
- Previous research has yielded conflicting results regarding this association.
Purpose of the Study:
- To conduct a meta-analysis evaluating the relationship between dietary cholesterol consumption and the risk of stroke.
- To clarify the controversial association between dietary cholesterol and stroke incidence.
Main Methods:
- A systematic literature search was performed across major databases (PubMed, Medline, Embase, Web of Knowledge, Google Scholar) up to September 2017.
- Seven prospective cohort studies involving 269,777 participants and 4,604 stroke events were included in the meta-analysis.
- Relative risk (RR) and 95% confidence intervals (CI) were calculated to quantify the association.
Main Results:
- Overall, higher dietary cholesterol intake (over 300 mg/day) showed no significant association with stroke risk (RR: 0.98, 95% CI: 0.90-1.07).
- A statistically significant increased risk of stroke was observed in females aged 60 years or older, or with a body mass index (BMI) of 24 kg/m² or higher, consuming over 300 mg/day of dietary cholesterol (RR: 1.18, 95% CI: 1.02-1.36).
Conclusions:
- Higher dietary cholesterol intake is not associated with overall stroke risk.
- Factors such as age and body mass index significantly modify the relationship between dietary cholesterol and stroke risk.
- The association between elevated dietary cholesterol and stroke risk in males requires further investigation.
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