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Impact of gender and genetics on emotion processing in Parkinson's disease - A multimodal study
Julia Heller1, Shahram Mirzazade1, Sandro Romanzetti1
1Department of Neurology, RWTH Aachen University, Pauwelsstraße 30, Aachen, Germany; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Germany.
Neuroimage. Clinical
|June 8, 2018
Abstract:
•Understanding of the phenotypic heterogeneity of Parkinson's disease is needed.•Gender and genetics determine manifestation and progression of Parkinson's disease.•Altered emotion processing in Parkinson's disease is specific to male patients.•This is influenced by endocrinal and genetic factors in both genders.•This finding may impact the diagnosis and treatment of emerging clinical features.
Keywords:
BAI, Beck anxiety inventoryBDI-II, Beck depression inventory version IIBFRT, Benton facial recognition testBOLD, blood‑oxygen-level dependentCOMT, catechol-O-methyltransferaseEPI, echo planar imagingEmotionFunctional magnetic resonance imaging (fMRI)GM, gray matterGenderGeneticsH&Y, Hoehn and Yahr rating scaleHC, healthy controlsLEDD, levodopa equivalence daily doseMCI, mild cognitive impairmentMMSE, Mini-Mental State ExaminationMRI, magnetic resonance imagingMoCA, Montreal Cognitive AssessmentNMS, non-motor symptomsPD, Parkinson's diseaseParkinson's disease (PD)UPDRS, Unified Parkinson's disease rating scaleVBM, voxel-based morphometryfMRI, functional magnetic resonance imaging