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Related Experiment Video

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Parietofrontal network upregulation after motor stroke.

M Bönstrup1, R Schulz2, G Schön3

  • 1Department of Neurology, University Medical Center Hamburg-Eppendorf, Germany; Human Cortical Physiology and Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

Neuroimage. Clinical
|June 8, 2018
PubMed
Summary

Stroke survivors show stronger parietofrontal connectivity during visually guided movements. This increased brain network coupling is linked to motor deficits, suggesting a role in post-stroke motor function and recovery.

Keywords:
CTC, communication through coherenceCoherenceDCM, dynamic causal modellingEEGLCMV, linear constrained minimum varianceLME, linear mixed effectsM1, primary motor cortexMVC, maximum voluntary contractionMotor recoveryNHP, Nine-Hole Peg Test performancePMv, ventral premotorParietal lobeSMA, supplementary motor areaStrokeTR-Coh, task-related coherenceTR-Pow, task-related spectral powerUEFM, Fugl–Meyer score upper extremity subsectionaIPS, anterior intraparietal sulcuscIPS, caudal intraparietal sulcus

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Area of Science:

  • Neuroscience
  • Motor Control
  • Neurorehabilitation

Background:

  • Motor recovery after stroke varies greatly between individuals.
  • Visuomotor integration, crucial for daily activities, involves parietal brain regions.
  • The parietal motor system's adaptation post-stroke is less understood than the frontal system.

Purpose of the Study:

  • To investigate plastic changes in functional connectivity within parietal and frontal motor areas after stroke.
  • To assess the behavioral relevance of these changes for motor function recovery.

Main Methods:

  • High-density electroencephalography (EEG) was used in 30 chronic stroke patients and 19 healthy controls.
  • Task-related coherence in sensorimotor rhythms was measured during a visually guided grip task.
  • Changes in functional connectivity were correlated with residual motor deficits.

Main Results:

  • Parietofrontal functional connectivity was significantly stronger in stroke patients compared to controls.
  • Task-related coherence between parietal and primary motor cortex increased in the stroke-lesioned hemisphere across sensorimotor rhythms.
  • This increased parietofrontal coupling positively correlated with motor impairment (Nine-Hole Peg Test, grip force).

Conclusions:

  • Stroke-lesioned brains exhibit enhanced parietofrontal motor system integration during visually guided movements.
  • The heightened connectivity may serve as a marker of motor network damage or influence post-stroke motor function.