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The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
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Decellularization of Whole Human Heart Inside a Pressurized Pouch in an Inverted Orientation
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How to break a mended heart.

Teresa Ojode1, Joshua W Sappenfield1

  • 1Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, United States.

Trauma Case Reports
|June 8, 2018
PubMed
Summary

Thoracic trauma can injure coronary bypass grafts, a rare but life-threatening condition. Prompt diagnosis and cardiac catheterization with stenting are crucial for managing these critical injuries.

Keywords:
Blunt chest traumaBlunt trauma-associated coronary injuryCoronary artery bypass graftInternal mammary arteries

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Area of Science:

  • Cardiology
  • Trauma Surgery
  • Vascular Surgery

Background:

  • Thoracic trauma can affect thoracic organs and great vessels, including coronary arteries.
  • Coronary bypass graft injuries are rare but potentially fatal consequences of thoracic trauma.
  • Diagnosis and management are complicated by the graft's nature, often unclear during emergencies.

Observation:

  • A case of occult, life-threatening coronary bypass graft injury from thoracic trauma is presented.
  • The patient required cardiac catheterization and an exclusionary stent for hemostasis.
  • Previous reports include native coronary injury and one medically managed bypass graft injury.

Findings:

  • Coronary bypass graft injuries from thoracic trauma are rare but life-threatening.
  • Cardiac catheterization and stenting can effectively manage these injuries with high suspicion.
  • Early cardiac studies in high-impact thoracic trauma patients with bypass grafts aid diagnosis.

Implications:

  • A high index of suspicion is vital for diagnosing coronary bypass graft injuries post-trauma.
  • Cardiac catheterization offers a viable management strategy for these critical injuries.
  • Enhanced diagnostic protocols for trauma patients with bypass grafts can improve outcomes.