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[Oncoproteins--the products of oncogenes. Tyrosine protein kinases]
Abstract:
The review summarizes the data mostly published in 1982 and 1983 concerning isolation, identification, cellular localization, deciphering of primary structure, and properties of the proteins coded by the retroviral oncogenes. A tentative classification of oncoproteins is suggested. The main part of the review is devoted to oncoproteins with tyrosine specific protein kinase activity. A hypothesis is proposed concerning the possible mode of action of these proteins on transforming cells. It is stressed in conclusion that the remarkable progress of our knowledge in this field has been mostly achieved due to recombinant DNA technique successfully and widely applied for studying oncogene structure and function.
Insights
This review covers retroviral oncogenes and their protein products, focusing on tyrosine-specific protein kinases. Recombinant DNA techniques have significantly advanced understanding of oncogene function in cell transformation.
Area of Science:
- Molecular Biology
- Virology
- Biochemistry
Context:
- Focuses on retroviral oncogenes and their protein products, primarily from research published in 1982-1983.
- Details the isolation, identification, cellular localization, primary structure, and properties of these proteins.
- Introduces a tentative classification of oncoproteins.
Purpose:
- To review and synthesize current knowledge on retroviral oncoproteins and their functions.
- To propose a hypothesis regarding the mechanism of action of tyrosine-specific protein kinases in cellular transformation.
- To highlight the impact of recombinant DNA technology on oncogene research.
Summary:
- Summarizes data on retroviral oncogenes, their protein products (oncoproteins), and their characteristics.
- Emphasizes oncoproteins with tyrosine-specific protein kinase activity and their potential role in cell transformation.
- Discusses the critical role of recombinant DNA techniques in advancing the study of oncogene structure and function.
Impact:
- Provides a foundational understanding of oncoproteins and their kinase activity.
- Suggests a mechanism for how these proteins contribute to cancer development.
- Underscores the power of molecular biology tools in unraveling complex biological processes.